Innovating for Impact: Exploring Gaps, Challenges, and Opportunities in Africa’s Clinical Trials and Research

Mar 31, 2025 | Blog

This past week was an inspiring whirlwind of travel, reflection, and discovery—a journey that affirmed my belief in Africa’s untapped potential to reshape global research and clinical trials to meet its own medical needs. Traveling with industry leaders and global health partners, I was struck by the genuine commitment of senior leaders who set aside their busy schedules to explore possibilities for meaningful change across the continent. 

Our first stop was Rwanda, a country that embodies resilience and ambition. Over the past 30 years, focused leadership has steered Rwanda from a period of conflict and instability towards building a new economy, and the energy here is palpable. In Rwanda, I witnessed firsthand the impact of sustained investment in public healthcare services. The nation’s young population and their determined commitment offer a hopeful outlook, even as they navigate the challenges of rapid growth.

Next, we journeyed to Zimbabwe, a nation whose story is both challenging and inspiring. After 25 years of economic isolation, Zimbabwe has been quietly rebuilding its economy, driven by the resilience and pioneering spirit of its people. Despite modest GDP growth projected at around 2–3% for 2024, Zimbabwe’s economic recovery over the last few years is evident in its determined efforts to harness local potential. In the healthcare sector, a growing proportion of of services in urban areas are delivered by the private sector, and a growing number of diaspora professionals are returning to provide high-quality care locally. Notably, Zimbabwe’s regulatory environment is forging new paths: its regulator is a founding and hosting member of ZAZIBONA, underscoring its commitment to partnering and harmonizing regionally. It also aiming high and working towards achieving ML4 status in its clinical trials division. This pioneering approach not only boosts local research capacity but also positions Zimbabwe as a critical player in the broader African clinical trial landscape, successfully competing with established regional hubs. 

Our final leg took us to South Africa, a country where the advantage of well-developed infrastructure is evident and continues to play a pivotal role in the region’s success. In Johannesburg, I observed a dynamic urban environment where modern amenities coexist with the challenges of servicing a growing population and providing equal opportunity to all South Africans. The robust infrastructure, combined with a vibrant private healthcare sector, positions South Africa as a cornerstone for medical research and innovation in Africa. 

Throughout our travels, we also visited cancer care centers in both Rwanda and Zimbabwe. It was disheartening to learn that each country, with populations of around 15 to 16 million, has only one public sector cancer institute. In Zimbabwe, for example, an under-resourced center—bolstered years ago by a generous donation from the Swiss government—continues to serve hundreds of patients daily. Yet, the dedication of visionary physicians, from those who envisioned improved cancer care in Rwanda a decade ago to pioneering oncologists in Harare who has persisted despite limited resources, fuels hope for transformative change. Collaborative research provides that opportunity providing access while improving standards and quality of care. 

I leave this trip with a deep sense of optimism. While Africa faces significant headwinds, the spirit of innovation, resilience, and commitment to advancing health is unmistakable. It is through these very challenges that opportunities for groundbreaking research and improved clinical care will emerge, ultimately benefiting not only Africa but our shared global community. 

 

by Taririo Makadzange – MD PhD | CEO ACRN